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SHBG-R

Meaning

SHBG-R refers to the Sex Hormone-Binding Globulin Receptor, a specific, distinct membrane receptor found on the surface of various target cells, particularly in the reproductive system and certain hormone-sensitive cancer cells. Unlike the classic function of SHBG as a circulating carrier protein for sex hormones, the SHBG-R mediates a rapid, non-genomic signaling pathway initiated when SHBG, with or without a bound steroid, interacts with this specific receptor. This unique interaction bypasses the traditional, slower nuclear receptor pathway.