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SHBG Genetic Variants

Meaning

SHBG Genetic Variants refer to the naturally occurring polymorphisms or single nucleotide variations (SNPs) found within the gene that codes for Sex Hormone-Binding Globulin (SHBG). These genetic differences influence the expression level and function of the SHBG protein, leading to significant inter-individual variations in the circulating concentration of SHBG. Since SHBG binds and regulates the bioavailability of sex steroids like testosterone and estrogen, these genetic variants can profoundly impact an individual’s free hormone levels and predispose them to various endocrine and metabolic conditions, such as Polycystic Ovary Syndrome (PCOS).