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SHBG Balancing

Meaning

SHBG Balancing refers to the clinical goal of optimizing the concentration of Sex Hormone-Binding Globulin (SHBG) to ensure appropriate bioavailability of crucial sex steroids, namely testosterone and estradiol, for target tissues. SHBG acts as a high-affinity transport protein, binding these hormones tightly and rendering them biologically inactive until they dissociate from the carrier molecule. Achieving appropriate balance ensures that a sufficient free hormone fraction is available to interact with intracellular and membrane receptors across the body. This measurement is a crucial metric in assessing true hormone status beyond merely looking at total circulating concentrations.