The complex neuroendocrine and vascular signaling network responsible for maintaining libido, arousal capacity, and overall sexual function throughout the lifespan. This signaling is highly sensitive to fluctuations in gonadal and adrenal hormones. It represents a critical marker of overall vitality.
Origin
This terminology specifically isolates the hormonal and neurological components required for healthy sexual expression, distinguishing it from general energy or mood. It acknowledges the deep integration between reproductive endocrinology and neurological drive.
Mechanism
Effective signaling relies heavily on appropriate pulsatile output from the $text{HPG}$ axis, leading to adequate levels of sex steroids like testosterone. Peripheral action involves robust androgen receptor sensitivity in target tissues. Furthermore, optimal vascular health, often supported by nitric oxide signaling, is required for the necessary hemodynamic changes associated with arousal.
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