A clinical endeavor focused on restoring and enhancing parameters related to libido, erectile function, fertility potential, and overall reproductive system vitality, particularly in the context of age-related endocrine decline. This process seeks to re-establish optimal circulating levels of sex hormones and their downstream effectors. Rejuvenation implies returning function toward a prior, more robust physiological state.
Origin
This concept originates from andrology and gynecology, increasingly integrated with anti-aging endocrinology as the link between systemic hormone status and sexual function becomes clearer. The term emphasizes a proactive, restorative approach rather than merely treating symptomatic dysfunction. It views sexual vitality as an index of overall systemic endocrine health.
Mechanism
The mechanism centers on normalizing the Hypothalamic-Pituitary-Gonadal (HPG) axis signaling to ensure appropriate pulsatile release of GnRH, LH, and FSH, leading to adequate gonadal steroidogenesis. Optimization may involve direct hormone replacement, use of aromatase inhibitors to manage estrogen dominance, or application of targeted peptides that influence local vascular and neural signaling in reproductive tissues. Restoring healthy nitric oxide pathways is also critical for vascular components of function.
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