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Sex Steroid Reduction

Meaning

Sex Steroid Reduction refers to a physiological or pharmacologically induced decrease in the circulating concentrations of the primary sex hormones, which include androgens like testosterone and estrogens like estradiol, within the systemic circulation. Physiologically, this reduction occurs naturally during the climacteric phases of life, such as andropause and menopause, while pharmacologically, it is often a therapeutic goal for hormone-sensitive malignancies. This reduction exerts a profound systemic impact on reproductive function, bone mineral density, muscle mass, and neurocognitive health.