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Sex Steroid Neuroprotection

Meaning

The inherent biological function of endogenous sex hormones, primarily estrogen, progesterone, and testosterone, to safeguard neurons against various forms of damage, including oxidative stress, excitotoxicity, and inflammation. This protective role is critical for maintaining cognitive function, neuronal survival, and resilience against neurodegenerative diseases throughout the lifespan. Declining sex steroid levels with age compromise this essential neuroprotective shield.