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Sex Steroid Depletion

Meaning

Sex Steroid Depletion is the physiological state characterized by abnormally low circulating concentrations of the primary gonadal hormones, including testosterone, estrogen, and progesterone. This depletion can be age-related, as seen in menopause and andropause, or pathologically induced by disease, surgery, or pharmacological intervention. Clinically, it results in a cascade of systemic effects, including loss of bone density, muscle atrophy, sexual dysfunction, and neurocognitive decline.