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Sex Hormone Stress Modulation

Meaning

Sex Hormone Stress Modulation is the bidirectional regulatory interaction between gonadal steroids (estrogen, progesterone, testosterone) and the hypothalamic-pituitary-adrenal (HPA) axis, the body’s central stress response system. This modulation describes how sex hormones influence the activity of the HPA axis and, conversely, how chronic stress-induced cortisol elevation impacts the synthesis and action of sex hormones. It is a critical component of endocrine resilience and gender-specific health outcomes. Understanding this interplay is vital for comprehensive hormonal health management.