The Sex Hormone Spectrum is the complete range of androgens, estrogens, and progestogens present in the human body, encompassing their precursors, active metabolites, and relative concentrations, which collectively dictate sex-specific characteristics and systemic function. This spectrum is highly dynamic, varying significantly across the lifespan, between sexes, and in response to health status and environment. A balanced spectrum is essential for reproductive, metabolic, cognitive, and musculoskeletal health.
Origin
This term is a modern clinical synthesis derived from the established field of steroid endocrinology, moving beyond the simple categorization of “male” or “female” hormones. “Spectrum” emphasizes the continuous, interconnected nature of these steroid molecules and their widespread biological effects across all individuals. It is a key concept in personalized hormonal health.
Mechanism
All sex hormones are synthesized from cholesterol via the steroidogenesis pathway, primarily in the gonads and adrenal glands. Enzymes like aromatase and 5-alpha reductase interconvert hormones, creating a complex metabolic web of active and inactive metabolites. The overall biological effect is determined by the relative concentrations of these hormones and their binding affinity to nuclear receptors in target tissues throughout the body.
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