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Sex Hormone-Binding Globulin Genetics

Meaning

Sex Hormone-Binding Globulin Genetics refers to the inherited variations, or polymorphisms, within the SHBG gene that influence the synthesis, structure, and circulating concentration of the primary sex hormone transport protein. These genetic factors dictate an individual’s baseline SHBG level, which in turn profoundly impacts the bioavailability of testosterone and estradiol by regulating the amount of free, active hormone. Understanding these genetics allows for a more personalized interpretation of total hormone laboratory results.