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Sex-Dependent Effects

Meaning

Sex-Dependent Effects refer to the differential physiological, pharmacological, or clinical outcomes that manifest uniquely based on an individual’s biological sex. In the hormonal health space, this means that the same therapeutic intervention, such as a diet change, exercise protocol, or hormone therapy dose, may produce distinct results in males versus females. These differences are primarily driven by the fundamental variance in sex hormone profiles and the resulting tissue-specific receptor expression and metabolic pathways. Recognizing these effects is essential for truly personalized and effective clinical practice.