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Serum Estradiol Monitoring

Meaning

Serum estradiol monitoring is the clinical practice of periodically measuring the concentration of estradiol (E2), the most potent naturally occurring estrogen, in the peripheral blood. This assessment is essential for managing female hormone replacement therapy, evaluating reproductive function, and monitoring treatment for conditions like hypogonadism or certain cancers. Precise monitoring is critical to maintain E2 levels within the individualized therapeutic range, thereby optimizing bone density and cardiovascular protection while mitigating the risks associated with excessive estrogen exposure. The measurement technique, often involving sensitive assays, must be appropriate for the low concentrations found in specific clinical contexts.