Serum Androgen Fractionation is the laboratory technique used to separate and quantify the various forms of androgens present in the blood, including total, free, and sex hormone-binding globulin (SHBG) bound fractions.
Origin
This detailed analysis evolved from basic clinical chemistry to provide a more nuanced view of biologically active hormone fractions beyond total assays.
Mechanism
Accurate fractionation is vital because only the unbound, free fraction of androgens is generally available to interact with tissue receptors, directly impacting drive and metabolic signaling.
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