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Serotonin Systems

Meaning

Serotonin systems refer to the extensive network of neurons and receptors that utilize the monoamine neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) for chemical signaling throughout the body. While widely known for its role in the central nervous system, modulating mood, sleep, and appetite, approximately ninety percent of the body’s serotonin is found in the enteric nervous system of the gut. This vast system influences gut motility, immune function, and is a key component of the microbiota-gut-brain axis. Maintaining balance in the serotonin systems is fundamental for both psychological and gastrointestinal well-being.