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Serotonin System Sensitivity

Meaning

Serotonin system sensitivity is the quantitative measure of how readily and strongly the central nervous system responds to the presence of the neurotransmitter serotonin, reflecting the functional efficiency of its receptors and associated signaling pathways. This sensitivity is a critical biological determinant of mood stability, emotional resilience, sleep architecture, and the regulation of appetite and satiety. Genetic polymorphisms, chronic stress, and nutritional factors can all significantly alter the functional sensitivity of this widespread neurochemical system.