What is the Origin of Serotonin Reuptake Transporter (SERT)?

The term is a descriptive combination of the neurotransmitter name, Serotonin, with the key physiological process, Reuptake, and the molecular structure, Transporter, which highlights its specific biological function. Its discovery was central to understanding the mechanism of action of many psychoactive medications.

What is the Mechanism of Serotonin Reuptake Transporter (SERT)?

SERT functions as a symporter, utilizing the electrochemical gradient of sodium and chloride ions to drive the movement of extracellular serotonin across the neuronal membrane and into the presynaptic terminal. Pharmacological agents, such as Selective Serotonin Reuptake Inhibitors (SSRIs), exert their therapeutic effect by blocking this transporter, thereby increasing the concentration and duration of serotonin's action on postsynaptic receptors.

Serotonin Reuptake Transporter (SERT) ∞ Area

Serotonin Reuptake Transporter (SERT)

Meaning

The Serotonin Reuptake Transporter (SERT) is a vital protein embedded in the membrane of presynaptic serotonergic neurons that is responsible for the active reuptake of the neurotransmitter serotonin (5-HT) from the synaptic cleft back into the neuron’s interior. This function is essential for regulating the concentration of serotonin in the synapse and terminating the neurotransmitter signal.