What is the Origin of Serotonin Reuptake Inhibitors?

This is a pharmacological descriptive term that precisely defines the drug's mechanism: the inhibition of the reuptake of serotonin. The development of these agents in the mid-20th century marked a significant advancement in the psychopharmacological understanding and treatment of mood disorders. They are also known as SSRIs, for Selective Serotonin Reuptake Inhibitors.

What is the Mechanism of Serotonin Reuptake Inhibitors?

By blocking the serotonin transporter (SERT) protein on the presynaptic membrane, SRIs prevent the rapid clearance of serotonin from the synapse. The resulting sustained presence of serotonin enhances its binding to postsynaptic receptors, facilitating improved communication within neural circuits that regulate mood, emotion, and behavior. This central nervous system modulation can also indirectly influence the hypothalamic-pituitary-adrenal axis.

Serotonin Reuptake Inhibitors

Meaning

Serotonin Reuptake Inhibitors (SRIs) are a class of psychotropic medications that function primarily by selectively blocking the reabsorption of the neurotransmitter serotonin by the presynaptic neuron in the central nervous system. This action increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. SRIs are widely prescribed for the clinical management of major depressive disorder, anxiety, and certain hormonal-related mood disturbances.