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Serotonin Norepinephrine Balance

Meaning

Serotonin Norepinephrine Balance refers to the essential, tightly regulated ratio and interaction between the two key monoamine neurotransmitters, serotonin (5-HT) and norepinephrine (NE), within the central nervous system. This equilibrium is fundamental for modulating a wide range of physiological and psychological functions, including mood, cognition, sleep architecture, appetite, and pain perception. A disruption in this delicate balance is a central hypothesis in the pathophysiology of major depressive disorder, anxiety disorders, and chronic pain syndromes.