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Serotonin Depletion

Meaning

Serotonin Depletion refers to a significant reduction in the levels of the neurotransmitter serotonin (5-hydroxytryptamine) within the central nervous system or in peripheral tissues. As a key monoamine, serotonin plays a profound role in regulating mood, sleep architecture, appetite, and gastrointestinal motility, all of which are closely intertwined with the endocrine system. Clinically, this depletion is often associated with the pathophysiology of depression, anxiety disorders, and certain sleep disturbances, highlighting the essential crosstalk between neurochemistry and hormonal balance.