Sermorelin is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH), a naturally occurring hypothalamic peptide. Its function is to stimulate the anterior pituitary gland to release its endogenous, pulsatile stores of Growth Hormone (GH). As a Growth Hormone Secretagogue, it promotes the physiological secretion of GH, which subsequently increases Insulin-like Growth Factor 1 (IGF-1) levels, supporting cellular repair, lean body mass, and metabolic health.
Origin
Sermorelin was initially developed in the late 20th century as a diagnostic tool to assess pituitary function, based on the structure and action of the naturally occurring GHRH. Its therapeutic use in age-related GH decline emerged as a safer, more physiological alternative to direct, exogenous GH administration, capitalizing on the body’s own regulatory mechanisms.
Mechanism
The peptide binds specifically to the GHRH receptors on the somatotroph cells within the anterior pituitary gland. This binding initiates a signaling cascade that culminates in the secretion of GH into the bloodstream in a pattern that closely mimics the body’s natural, pulsatile release. Because it requires a functional pituitary gland, it maintains the negative feedback loop involving IGF-1, which helps prevent the over-secretion and potential side effects associated with supraphysiological GH dosing.
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