What is the Origin of Sermorelin Growth Factor?

Sermorelin is derived from the N-terminal segment of the naturally occurring human GHRH molecule, designed for stability and efficacy in administration. Its creation was intended to provide a pharmacologically active compound that mimics the physiological stimulus for GH release without inducing the complex negative feedback associated with exogenous GH administration. The designation "factor" denotes its role in influencing the release cascade of growth hormone.

What is the Mechanism of Sermorelin Growth Factor?

The mechanism involves Sermorelin binding to the GHRH receptor located on anterior pituitary somatotroph cells, activating the adenylyl cyclase pathway, which subsequently increases intracellular cyclic AMP (cAMP) concentration. This second messenger cascade ultimately leads to the regulated exocytosis of pre-formed GH vesicles into the systemic circulation. Importantly, because it mimics the natural hypothalamic signal, Sermorelin preserves the natural pulsatile pattern of GH secretion.

Sermorelin Growth Factor ∞ Area

Sermorelin Growth Factor

Meaning

Sermorelin is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH) used clinically to stimulate the pituitary gland’s intrinsic production and release of endogenous Growth Hormone (GH). It acts as a diagnostic tool to assess somatotropic axis integrity or as a therapeutic agent to support natural GH secretion patterns. This peptide is crucial when investigating potential growth hormone deficiencies that stem from hypothalamic signaling issues.