What is the Origin of Sermorelin GH Stimulation?

Sermorelin is a synthetic peptide mimicking the first 29 amino acids of native Growth Hormone-Releasing Hormone (GHRH). 'GH Stimulation' describes the intended physiological effect—provoking growth hormone secretion.

What is the Mechanism of Sermorelin GH Stimulation?

Sermorelin acts by binding specifically to the GHRH receptor located on the surface of pituitary somatotroph cells. This binding activates the adenylyl cyclase pathway, leading to an increase in intracellular cyclic AMP (cAMP). Elevated cAMP levels then initiate the cascade necessary for the synthesis and exocytosis of preformed GH stores, resulting in a measurable surge of GH into the systemic circulation. The magnitude of this surge reflects the health and functional capacity of the pituitary gland.

Sermorelin GH Stimulation ∞ Area

Sermorelin GH Stimulation

Meaning

Sermorelin GH Stimulation refers to the diagnostic or therapeutic use of Sermorelin, a synthetic GHRH analog, to provoke a measurable release of endogenous Growth Hormone (GH) from the anterior pituitary gland. This procedure is used clinically to assess the functional reserve of the somatotroph axis, particularly when baseline GH levels are low or questionable. It provides direct evidence of pituitary responsiveness to hypothalamic stimulation.