What is the Origin of Sermorelin Endogenous GH?

Sermorelin was synthesized as a fragment of the naturally occurring GHRH, discovered in the 1980s. The term "endogenous GH" is used to distinguish the resulting release from the direct injection of recombinant human GH.

What is the Mechanism of Sermorelin Endogenous GH?

Sermorelin binds to the GHRH receptors on the somatotroph cells of the anterior pituitary. This binding initiates a cascade that causes the pituitary to release a pulse of stored GH into the circulation. This mechanism maintains the natural feedback loop of the somatotropic axis, minimizing the risk of pituitary suppression that can occur with direct exogenous GH administration.

Sermorelin Endogenous GH ∞ Area

Sermorelin Endogenous GH

Meaning

The clinical effect of the peptide Sermorelin, a Growth Hormone-Releasing Hormone (GHRH) analog, which specifically stimulates the pituitary gland to release its own stored, naturally produced Growth Hormone (GH). This therapeutic approach utilizes an exogenous agent to enhance endogenous (internal) GH pulsatility, promoting the benefits of GH without introducing the exogenous hormone itself. It is a physiological method of somatotropic axis enhancement.