What is the Origin of SERCA2?

The term is an acronym derived from the enzyme's function and location: 'Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2'. Its study is central to cellular physiology, muscle contraction, and calcium signaling pathways.

What is the Mechanism of SERCA2?

SERCA2 functions as an ATP-driven ion pump, hydrolyzing one molecule of ATP to provide the energy required to transport two calcium ions into the SR/ER lumen. In cardiac and skeletal muscle, this rapid reduction of cytosolic calcium concentration is necessary for relaxation following contraction. The activity and expression of SERCA2 are subject to regulation by various hormones, such as thyroid hormone, thereby linking the endocrine system to the fundamental efficiency of cellular calcium handling and cardiac output.

SERCA2 ∞ Area

SERCA2

Meaning

SERCA2 is the abbreviation for the Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2, a crucial enzyme embedded in the membrane of the sarcoplasmic or endoplasmic reticulum (SR/ER) of cells. Its primary function is to actively pump calcium ions from the cytoplasm back into the SR/ER lumen against a steep concentration gradient. This reuptake is essential for terminating calcium-dependent signaling events, facilitating muscle relaxation, and maintaining overall cellular calcium homeostasis.