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Sepranolone

Meaning

A novel synthetic neurosteroid antagonist currently under investigation for its potential therapeutic application in treating premenstrual dysphoric disorder (PMDD) and other conditions linked to neurosteroid dysregulation. It is specifically designed to block the effects of allopregnanolone, a potent positive allosteric modulator of the GABA-A receptor, thereby aiming to normalize excessive inhibitory signaling in the central nervous system.