What is the Origin of Sensitization?

This term originates from general pharmacology and immunology, describing the process of becoming more reactive to a specific stimulus over time or through preparatory exposure within a biological system.

What is the Mechanism of Sensitization?

In physiology, sensitization can be a positive adaptation; for instance, improving insulin sensitivity through exercise enhances glucose disposal without requiring excessive pancreatic beta-cell output. Conversely, chronic low-level exposure to certain endocrine disruptors can sometimes lead to inappropriate cellular sensitization to those xenobiotics, altering normal signaling.

Sensitization ∞ Area

Sensitization

Meaning

Sensitization, in the context of hormonal regulation, denotes an increase in the responsiveness of target tissues to a given concentration of a hormone or signaling molecule, often achieved through increased receptor expression or enhanced downstream signaling fidelity.