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Sensitive Assay Estradiol

Meaning

Sensitive Assay Estradiol refers to a laboratory measurement of the hormone estradiol (E2) performed using an analytical method, typically liquid chromatography-tandem mass spectrometry (LC-MS/MS), that possesses significantly higher precision and a lower limit of detection than standard immunoassays. This specialized testing is clinically necessary for accurately quantifying the very low circulating E2 concentrations found in men, postmenopausal women, or children, where standard assays often produce unreliable results due to cross-reactivity or poor sensitivity. It is the gold standard for precision hormonal assessment in these populations.