What is the Origin of Senotherapeutic Peptides?

This term is a portmanteau of "senescence" (aging) and "therapeutic," arising from the cutting-edge field of gerontology and peptide chemistry. The development of these peptides is directly linked to the scientific identification of the "hallmarks of aging" and the search for compounds that can safely intervene in these fundamental processes. They represent a pharmacological approach to longevity.

What is the Mechanism of Senotherapeutic Peptides?

The primary mechanism involves either senolytic action, selectively inducing apoptosis in harmful senescent cells that accumulate with age, or senomorphic action, which alters the phenotype of senescent cells to reduce their inflammatory secretions. Other senotherapeutic peptides may act by enhancing cellular repair mechanisms like autophagy or by modulating growth factor signaling to promote tissue regeneration. The goal is to restore a more youthful cellular microenvironment.

Senotherapeutic Peptides

Meaning

Senotherapeutic Peptides are a class of short-chain amino acid compounds specifically designed or identified to target and modulate the cellular and molecular processes associated with senescence, the biological aging process. These agents are distinct in their function, aiming to clear senescent cells, improve cellular resilience, or activate longevity pathways. Their clinical utility lies in mitigating age-related dysfunction and extending the functional healthspan.