What is the Origin of Senomorphic Therapy?

The term is a compound word, combining "seno," referring to senescence or aging, and "morphic," meaning to shape or alter. It emerged as a distinct category of anti-aging intervention alongside senolytics, which directly kill senescent cells. This concept gained clinical relevance with the discovery of the SASP and the subsequent realization that simply altering the inflammatory output of these cells could yield significant health benefits.

What is the Mechanism of Senomorphic Therapy?

Senomorphic agents typically work by inhibiting the signaling pathways, such as NF-κB or mTOR, that are responsible for driving the production and secretion of the pro-inflammatory SASP factors. By silencing this harmful secretory profile, the therapy reduces chronic, sterile inflammation throughout the body, which in turn improves metabolic function, enhances tissue repair, and mitigates the progression of age-related diseases. The mechanism focuses on neutralizing the cell's toxic effect on its microenvironment.

Senomorphic Therapy ∞ Area

Senomorphic Therapy

Meaning

Senomorphic Therapy is a novel class of therapeutic interventions specifically designed to alter the phenotype and function of senescent, or aging, cells without necessarily causing their immediate death. Senescent cells accumulate with age, secrete a harmful mix of pro-inflammatory molecules known as the Senescence-Associated Secretory Phenotype (SASP), and drive chronic inflammation and tissue dysfunction. The goal of senomorphic agents is to suppress the SASP, thereby mitigating the detrimental systemic effects of cellular aging and improving the function of surrounding tissues. This approach is a key strategy in modern longevity medicine.