What is the Origin of Senolytics Therapy?

This term is a portmanteau of 'senescence' (biological aging) and 'lytic' (to dissolve or destroy), originating from the field of geroscience and aging research. It represents one of the most promising avenues in longevity medicine for directly targeting a fundamental hallmark of aging.

What is the Mechanism of Senolytics Therapy?

Senolytic agents work by disrupting the pro-survival pathways that senescent cells employ to resist apoptosis, even though they are metabolically dysfunctional. By inhibiting these pathways, such as Bcl-2 family proteins, the therapy forces the senescent cells to undergo programmed death. The subsequent clearance of these cells by the immune system reduces the pathological inflammation and tissue damage caused by the Senescence-Associated Secretory Phenotype (SASP), leading to measurable tissue rejuvenation.

Senolytics Therapy ∞ Area

Senolytics Therapy

Meaning

Senolytics Therapy involves the use of pharmacological or nutritional compounds, known as senolytics, specifically designed to selectively induce apoptosis, or programmed cell death, in senescent cells. Senescent cells are dysfunctional cells that accumulate with age, secrete pro-inflammatory factors (SASP), and contribute significantly to tissue aging and chronic disease. The clinical goal of this therapy is to reduce the body’s senescent cell burden, thereby improving tissue function and potentially extending healthspan.