What is the Origin of Senolytics Protocols?

This term is derived from the pioneering field of senescence research, combining the root 'seno' (old age) with 'lytic' (to destroy). The concept of using small molecules to selectively target and eliminate senescent cells is a recent and major development in longevity science. 'Protocols' refers to the structured, often cyclical, dosing regimens used in clinical practice.

What is the Mechanism of Senolytics Protocols?

Senescent cells resist natural apoptosis by upregulating pro-survival pathways. Senolytic agents work by disrupting these specific pro-survival mechanisms, thereby forcing the senescent cells into apoptosis. Once cleared, the inflammatory environment they created is reduced, allowing surrounding healthy tissue to function more optimally and promoting tissue regeneration.

Senolytics Protocols ∞ Area

Senolytics Protocols

Meaning

Senolytics Protocols refer to the clinical application of compounds or agents, known as senolytics, specifically designed to selectively induce programmed cell death (apoptosis) in senescent cells. These dysfunctional cells accumulate with age and drive chronic inflammation and tissue damage. The goal of these protocols is to clear the body’s burden of senescent cells, thereby reducing systemic inflammation and potentially delaying age-related diseases.