What is the Origin of Senolytics Compounds?

The term is a compound of the Latin senex (old) and the Greek lysis (to loosen or break down), directly translating to "old cell destroyer." This area of research gained significant traction in the early 2010s as a promising strategy in the biology of aging. Senolytics represent a molecular approach to address a fundamental driver of age-related pathology.

What is the Mechanism of Senolytics Compounds?

Senescent cells resist natural apoptosis by activating a unique set of pro-survival pathways, often termed the Senescence Anti-Apoptotic Pathways (SAAPs). Senolytics work by inhibiting these specific SAAPs, thus stripping the senescent cells of their protective mechanisms and allowing them to undergo apoptosis. The targeted elimination of these cells reduces the Senescence-Associated Secretory Phenotype (SASP), thereby lowering chronic, sterile inflammation and restoring tissue function.

Senolytics Compounds ∞ Area

Senolytics Compounds

Meaning

Senolytics Compounds are a class of therapeutic agents specifically designed to selectively induce apoptosis, or programmed cell death, in senescent cells. Senescent cells are damaged cells that have ceased dividing but remain metabolically active, secreting pro-inflammatory molecules that contribute to tissue dysfunction and aging. The clinical goal of senolytics is to clear this toxic cellular burden to promote tissue rejuvenation and healthspan extension.