What is the Meaning of Senolytics?

Senolytics are a novel class of therapeutic compounds specifically engineered to selectively induce apoptosis, or programmed cell death, in senescent cells—cells that have ceased dividing but remain metabolically active and secrete damaging pro-inflammatory molecules. The clinical objective is to clear these dysfunctional cells from tissues to mitigate chronic inflammation and promote a state of tissue rejuvenation. They represent a significant advancement in geroscience.

What is the Origin of Senolytics?

The term is a compound derived from the Latin senex (old) and the Greek lysis (to loosen or dissolve), literally translating to "old cell dissolvers." This terminology was coined in the 21st century, marking a significant, deliberate shift toward targeting the cellular mechanisms of aging. This conceptualization offers a new pathway for longevity interventions.

What is the Mechanism of Senolytics?

Senolytic agents exert their action by targeting specific anti-apoptotic pathways, such as the PI3K/AKT or Bcl-2 family, that senescent cells uniquely rely on for their continued survival. By inhibiting these pathways, the compounds effectively tip the cellular balance toward programmed death. This targeted clearance mechanism removes the source of the Senescence-Associated Secretory Phenotype (SASP), thereby reducing systemic inflammation and facilitating the regeneration of healthy tissue.

Senolytics ∞ Area

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Senolytics

Meaning

Origin

Mechanism

The Unwritten Rules of Biological Time Reversal

Aging Is a Failure of Communication

Defying Age through Cellular Command

Your Biological Age Is Your True North

Your Prime Is a Choice You Make at the Cellular Level

Defy Age the Smart Way

Your Body’s New Rules for Time

The New Science of Biological Age Reversal

Age Is a Concept Biological Optimization Is Your Reality

Beyond Age Cellular Recalibration

Mastering Internal Chemistry for Timeless Vitality

Longevity Reimagined through Science

Reversing Your Chronological Clock

Master Your Biology: The Age-Defying Blueprint

Elevating Biology beyond Chronological Limits

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