Senolytic Therapy Applications refer to the clinical use of specific compounds or interventions designed to selectively induce apoptosis, or programmed cell death, in senescent cells. These “zombie cells” accumulate with age, secrete pro-inflammatory cytokines, and contribute significantly to chronic inflammation and tissue dysfunction, which in turn disrupt hormonal signaling. The therapeutic goal is to clear this senescent cell burden to reduce the inflammatory load, rejuvenate tissue microenvironments, and thereby improve overall hormonal and metabolic health. This is a frontier approach in longevity medicine.
Origin
The term “senolytic” is a portmanteau of “senescence” (biological aging) and “lytic” (destroying), first coined to describe compounds with this specific action. The concept originated in aging research, where the causal link between senescent cells and age-related pathology was established. Its application in hormonal health is based on the understanding that chronic inflammation drives endocrine resistance.
Mechanism
Senolytic agents work by targeting the specific anti-apoptotic pathways that senescent cells employ to resist natural cell death, such as the Bcl-2 family of proteins. By disrupting these survival pathways, the agents trigger the cell’s internal apoptotic cascade. The subsequent clearance of these inflammatory cells by the immune system reduces the systemic secretome, which is a collection of pro-inflammatory and matrix-degrading molecules, leading to a healthier tissue environment and improved cellular communication.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.