What is the Origin of Senolytic Therapy Application?

This term is a combination of 'senescence' (aging) and 'lytic' (destroying), originating from the field of geroscience and the study of cellular aging. The 'application' denotes the translation of this cellular concept into a practical therapeutic modality for age-related conditions.

What is the Mechanism of Senolytic Therapy Application?

Senolytic compounds function by targeting the pro-survival pathways that senescent cells employ to resist apoptosis, pathways collectively known as Senescence-Associated Anti-Apoptotic Pathways (SAAPs). By inhibiting these survival mechanisms, the senescent cells become vulnerable and undergo apoptosis, allowing phagocytic cells to clear them from the tissue. The subsequent reduction in the senescent cell burden and their SASP signaling can lead to improved tissue function and reduced systemic inflammation.

Senolytic Therapy Application ∞ Area

Senolytic Therapy Application

Meaning

Senolytic Therapy Application refers to the clinical use of specific compounds or interventions designed to selectively induce programmed cell death, or apoptosis, in senescent cells. These are aged, non-dividing cells that accumulate in tissues and secrete harmful pro-inflammatory factors. The application of senolytics is a novel strategy in longevity medicine aimed at clearing these dysfunctional cells to rejuvenate tissues and combat age-related pathology, thereby improving healthspan.