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Senolytic Therapies

Meaning

A novel class of therapeutic interventions specifically designed to selectively induce apoptosis (programmed cell death) in senescent cells, often referred to as “zombie cells,” while carefully sparing healthy, functional cells. By clearing these dysfunctional cells, senolytic therapies aim to reduce the systemic burden of the Senescence-Associated Secretory Phenotype (SASP) and the chronic low-grade inflammation it causes. This is a leading, targeted strategy in the clinical pursuit of longevity and anti-aging.