What is the Origin of Senolytic Peptide Targets?

Senolytic is a portmanteau derived from senescence (aging) and lysis (destruction). Peptide targets refer to the specific molecular sites these therapeutic peptides are designed to interact with on the senescent cell surface or within its internal machinery.

What is the Mechanism of Senolytic Peptide Targets?

The mechanism involves peptides binding to receptors or signaling molecules unique to senescent cells, often those involved in evading apoptosis, such as the p53 or p16 pathways. Upon binding, the peptide initiates a cascade leading to programmed cell death, clearing the dysfunctional cells from the tissue microenvironment. This removal reduces chronic inflammation, thereby improving the local hormonal signaling milieu.

Senolytic Peptide Targets ∞ Area

Senolytic Peptide Targets

Meaning

Identification and targeting of specific cellular pathways or markers that are amenable to intervention by senolytic peptides, which are molecules designed to selectively induce apoptosis in senescent cells. Senescent cells accumulate with age and secrete pro-inflammatory factors, contributing to systemic entropy. Targeting these cells is a key strategy in longevity science aimed at improving tissue function and overall healthspan. This is a focused application within regenerative endocrinology.