What is the Origin of Senolytic Lifestyle?

The term is a synthesis of "senolytic" (the selective destruction of senescent cells) and "lifestyle," emerging from the field of geroscience, which posits that targeting the hallmarks of aging, like cellular senescence, is the key to extending healthspan. It translates advanced molecular biology into actionable, preventative health behaviors.

What is the Mechanism of Senolytic Lifestyle?

The lifestyle acts through multiple synergistic pathways; for instance, prolonged fasting periods and certain polyphenols can trigger cellular clearance pathways like autophagy, which helps eliminate damaged or pre-senescent cells. Intense, short-duration exercise can also modulate immune surveillance, aiding in the effective removal of senescent cells. By reducing the overall SASP burden, this lifestyle lowers systemic, chronic inflammation, which is a major, recognized driver of age-related endocrine dysfunction and metabolic decline.

Senolytic Lifestyle ∞ Area

Senolytic Lifestyle

Meaning

A senolytic lifestyle is a comprehensive, proactive health strategy focused on minimizing the accumulation of senescent cells—cells that have ceased dividing but remain metabolically active and secrete a pathological mix of pro-inflammatory factors (SASP). This lifestyle incorporates evidence-based practices, such as specific nutritional timing, targeted supplementation, and regular physical activity, that are known to either induce apoptosis in senescent cells or suppress the inflammatory SASP. The clinical goal is to reduce chronic, sterile inflammation and fundamentally slow the biological aging process.