What is the Origin of Senolytic Interventions?

This term was coined following the discovery of the first compounds that could selectively kill senescent cells without harming healthy, proliferating cells. This groundbreaking work validated the Geroscience Hypothesis by demonstrating that clearing senescent cells could alleviate multiple age-related pathologies in animal models. The term is fundamentally a fusion of "senescence" and "lytic," meaning to break down or destroy, reflecting the direct therapeutic action.

What is the Mechanism of Senolytic Interventions?

Senolytic Interventions function by exploiting the unique pro-survival pathways that senescent cells activate to resist their own programmed death. These interventions inhibit these specific anti-apoptotic pathways, causing the senescent cells to undergo apoptosis and be cleared by the immune system. By removing these dysfunctional, pro-inflammatory cells, the tissue microenvironment is rejuvenated, improving stem cell function, reducing systemic inflammation, and enhancing overall tissue repair capacity.

Senolytic Interventions

Meaning

Senolytic Interventions are targeted pharmacological or nutritional strategies specifically designed to selectively induce apoptosis, or programmed cell death, in senescent cells—cells that have ceased dividing but remain metabolically active and secrete detrimental pro-inflammatory factors. The clinical goal of these interventions is to reduce the overall senescent cell burden in tissues, thereby mitigating chronic inflammation, restoring tissue function, and slowing the progression of age-related diseases. These interventions represent a cutting-edge approach in geroscience and longevity medicine.