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Senolytic Intervention Theory

Meaning

Senolytic Intervention Theory posits that the selective induction of apoptosis—programmed cell death—in senescent cells can slow, halt, or potentially reverse age-related tissue dysfunction and disease. Senescent cells, often termed ‘zombie cells,’ have permanently ceased dividing but remain metabolically active, secreting a harmful mix of pro-inflammatory molecules that damage surrounding tissue. A senolytic intervention, typically a specific pharmacological agent, is precisely designed to induce apoptosis specifically in these dysfunctional cells, thereby clearing the senescent burden and restoring the healthy tissue microenvironment. This is a targeted strategy for systemic rejuvenation.