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Senolytic Clearance Protocols

Meaning

Senolytic clearance protocols are therapeutic interventions, often involving specific compounds or transient lifestyle modifications, designed to selectively induce apoptosis, or programmed cell death, in senescent cells—cells that have ceased dividing but remain metabolically active and secrete pro-inflammatory molecules. These protocols are a key strategy in longevity medicine, aiming to reduce the systemic “senescence-associated secretory phenotype” (SASP), which includes pro-inflammatory cytokines and altered hormonal signaling that drive chronic aging and disease. Efficient clearance is essential for tissue rejuvenation.