Senolytic Cellular Therapy is a pioneering medical strategy focused on the selective elimination of senescent cells—cells that have permanently ceased dividing but remain metabolically active and secrete a potent mix of pro-inflammatory molecules, contributing directly to tissue aging and systemic dysfunction. These therapies aim to significantly reduce the body’s overall senescent cell burden, thereby mitigating chronic low-grade inflammation, restoring a more youthful tissue microenvironment, and improving regenerative capacity. Clinical research explores this intervention as a direct, mechanistic method for slowing the fundamental biological aging process and preventing a broad spectrum of age-related diseases.
Origin
The term combines “Senolytic,” derived from the Latin senex (old) and the Greek lysis (to loosen or break down), literally meaning “old-cell breaking,” with “Cellular Therapy,” indicating a treatment that targets specific cell populations. This concept emerged from groundbreaking gerontology research identifying cellular senescence as a fundamental, actionable hallmark and driver of the human aging process.
Mechanism
Senolytic agents function by precisely exploiting the unique pro-survival pathways that senescent cells employ to resist apoptosis (programmed cell death). By selectively inhibiting these specific anti-apoptotic mechanisms, the senolytic compound triggers the targeted, self-destruction of the dysfunctional senescent cell. This targeted clearance reduces the chronic release of the detrimental Senescence-Associated Secretory Phenotype (SASP) factors, which are known to drive inflammation and damage adjacent healthy tissue.
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