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Senolytic Activation Theory

Meaning

The Senolytic Activation Theory posits that the highly targeted pharmacological or biological induction of apoptosis—programmed cell death—specifically in senescent cells is a viable, effective, and transformative strategy for mitigating age-related dysfunction and promoting significant tissue rejuvenation. Senescent cells, which have permanently ceased dividing but remain metabolically active and secrete harmful factors, are conclusively identified as a primary, causal driver of aging pathology. The theory suggests that their selective and systematic removal can effectively restore systemic tissue homeostasis and functional integrity.