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Senolysis

Meaning

Senolysis is the selective pharmacological or immunological process of eliminating senescent cells (SnCs), which are aged, non-dividing cells that accumulate in tissues and secrete a detrimental pro-inflammatory mixture known as the Senescence-Associated Secretory Phenotype (SASP). This process is a key strategy in geroscience aimed at reducing the burden of SnCs to delay, prevent, or treat a wide array of age-related diseases and extend overall healthspan. Senolysis is achieved through the use of specific compounds collectively termed senolytics.