What is the Origin of Senescent Cell Clearance Support?

This concept is central to the emerging field of geroscience and longevity medicine, focusing on cellular senescence as a primary driver of age-related disease. Senescent is derived from the Latin senescere, meaning to grow old. Clearance refers to the removal of unwanted substances.

What is the Mechanism of Senescent Cell Clearance Support?

Support mechanisms include activating natural cellular pathways like apoptosis or stimulating the immune system's phagocytic cells to engulf and eliminate senescent cells. Compounds known as senolytics are specifically developed to induce apoptosis in these dysfunctional cells. Reducing the burden of senescent cells decreases the systemic SASP, thereby mitigating tissue damage and supporting the hormonal milieu.

Senescent Cell Clearance Support ∞ Area

Senescent Cell Clearance Support

Meaning

Senescent Cell Clearance Support refers to the physiological and therapeutic strategies aimed at promoting the efficient removal of senescent, or ‘zombie,’ cells from tissues and organs. These cells have permanently ceased dividing but remain metabolically active, secreting a pro-inflammatory Senescence-Associated Secretory Phenotype (SASP). Effective clearance is a crucial anti-aging mechanism that reduces chronic inflammation and preserves tissue function.