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Senescent Cell Clearance Signaling

Meaning

Senescent Cell Clearance Signaling refers to the complex biological pathways and molecular signals that trigger the selective removal of senescent cells, which are cells that have ceased dividing but remain metabolically active and secrete pro-inflammatory factors. The efficient clearance of these cells, often called “zombie cells,” is crucial for tissue renewal and preventing the chronic, low-grade inflammation associated with aging, known as inflammaging. Maintaining robust clearance signaling is a key strategy in promoting healthspan and tissue longevity by reducing the burden of cellular dysfunction.