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Senescence Resistance

Meaning

Senescence Resistance is the biological capacity of cells and tissues to actively oppose or significantly delay the process of cellular senescence, which is a state of irreversible growth arrest often accompanied by the secretion of pro-inflammatory molecules. This resistance is a crucial determinant of tissue health and functional lifespan, preventing the accumulation of dysfunctional cells that contribute directly to age-related disease and frailty. Clinical strategies aim to bolster this intrinsic cellular defense mechanism to maintain tissue vitality and functional reserve capacity.