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Senescence Rejection

Meaning

Senescence Rejection is a proactive biological and clinical strategy focused on preventing or reversing cellular senescence, a state where cells permanently stop dividing but remain metabolically active and secrete pro-inflammatory and tissue-degrading factors. This intervention targets the clearance of these senescent cells and the suppression of the Senescence-Associated Secretory Phenotype (SASP), thereby mitigating chronic inflammation and preserving tissue function. It is a core tenet of longevity medicine aimed at reducing biological aging.