What is the Origin of Senescence Markers Reduction?

This term is rooted in gerontology and molecular biology, focusing on the state of senescence, derived from the Latin senescere, meaning "to grow old." The clinical goal is the measurable reduction of the molecular signatures that define this aging state.

What is the Mechanism of Senescence Markers Reduction?

Senolytics, a class of compounds, operate by selectively inducing apoptosis in senescent cells, thereby clearing the accumulated dysfunctional cells from tissues. This targeted removal directly reduces the burden of SASP, which is responsible for propagating chronic, low-grade inflammation in the surrounding microenvironment. The resulting reduction in senescence markers improves tissue function and promotes a healthier, more regenerative cellular landscape.

Senescence Markers Reduction ∞ Area

Senescence Markers Reduction

Meaning

Senescence Markers Reduction is the clinical and therapeutic goal of decreasing the quantifiable biological indicators associated with cellular senescence, a state of irreversible growth arrest often triggered by stress or damage. These markers include the accumulation of p16Ink4a, increased senescence-associated β-galactosidase activity, and the secretion of the pro-inflammatory Senescence-Associated Secretory Phenotype (SASP). The reduction of these markers is a key strategy in longevity medicine aimed at slowing age-related tissue dysfunction.